Endometrial receptivity testing 

What is endometrial receptivity testing?

The readiness of the uterine lining is crucial for successful embryo implantation and pregnancy.

In comparison to conventional ultrasound examination, which only evaluates the height / strength and structure of the inner uterus lining, endometrial receptivity testing provides more accurate information about the state of the tissue. 

At PFC, we currently use two variants of the test, the ERA test (Endometrial receptivity array/​analysis) and the beReady test. Both tests analyse, according to studies, all 236 major genes that, at the molecular level, determine if the endometrial mucosa can accept an embryo. With this detailed information, we can then more accurately determine the best time for embryo transfer and tailor an IVF treatment plan to each couple’s specific needs.

The ERA test and the beReady test are specialised methods for optimising transfer and subsequent nesting. Genetic analysis of uterine lining receptivity is chosen when there are repeated unsuccessful transfers, numbering two or more, and neither genetic testing of the embryo (PGT‑A, PGT‑M, PGT-SR tests), blood tests nor ultrasound examination of the uterine mucosa reveal the cause of failure to nest.

How receptivity testing works:

• Endometrial receptivity testing requires a biopsy (sampling) of the uterine lining at a specific, precisely scheduled secretory phase of the menstrual cycle. The biopsy is performed with a very thin plastic pipette without anaesthesia by inserting it through the cervix into the uterus. The collection is optimally performed on the 5^th day after the start of progesterone supplementation in a cycle with stimulation.
• Within 2 weeks we know the results and are able to accurately determine the next implantation window.

If you have had several unsuccessful transfers and are wondering what other options are available in your individual case, please contact our IVF Coordinators who will organise a personal consultation with a doctor. Together we will look for your personal pathway to a successful conception.